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目的探讨类风湿关节炎(RA)患者伴甲状腺功能异常的临床特点。方法选取2013年3月至2016年11月广州医科大学附属惠州医院收治的35例RA合并甲状腺功能异常患者作为观察组,同时选取35例正常体检的健康者作为对照组,检测两组受试者甲状腺抗体、甲状腺功能、实验室指标。结果观察组患者RA评分、甲状腺球蛋白抗体(TgAb)、甲状腺过氧化物酶抗体(TPOAb)水平均明显高于对照组,差异均有统计学意义(均P<0.05);观察组患者游离三碘甲状腺原氨酸(FT_3)、游离甲状腺素(FT_4)及促甲状腺激素(TSH)水平均明显低于对照组,差异均有统计学意义(均P<0.05)。结论类风湿关节炎患者并发甲状腺功能异常的情况应该引起广大医务工作者的重视,做好相关甲状腺功能及抗体筛查检测,并进行积极治疗,以改善预后。
Objective To investigate the clinical features of rheumatoid arthritis (RA) patients with thyroid dysfunction. Methods Thirty-five patients with RA combined with thyroid dysfunction admitted to Huizhou Hospital, Guangzhou Medical University from March 2013 to November 2016 were selected as the observation group, and 35 normal healthy controls were selected as the control group. Two groups of subjects Thyroid antibodies, thyroid function, laboratory indicators Results The scores of RA, thyroglobulin antibody (TgAb) and thyroid peroxidase antibody (TPOAb) in the observation group were significantly higher than those in the control group (all P <0.05). In the observation group, The levels of thyroid acid (FT_3), free thyroxine (FT_4) and thyroid stimulating hormone (TSH) were significantly lower than those of the control group (all P <0.05). Conclusions Patients with rheumatoid arthritis complicated by thyroid dysfunction should arouse the attention of the majority of medical workers, do a good job related thyroid function and antibody screening tests, and active treatment to improve the prognosis.