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将6种金鸡纳生物碱-9-O-三甲基硅(TMS)衍生物用于催化环己二酮与溴乙酰甲酸乙酯/β取代的溴乙酰甲酸乙酯的不对称“中断的”Feist-Bénary反应,得到了高的化学产率(85%～97%)和最高达90%ee的立体选择性。
Six cinchona alkaloid-9-O-trimethylsilyl (TMS) derivatives were used to catalyze the asymmetry of cyclohexanedione with ethyl bromoacetate / beta-substituted ethyl bromoacetate "Feist-Bénary reaction, high stereochemical selectivity (85% ~ 97%) and stereoselectivity of up to 90% ee were obtained.