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目的探讨C-反应蛋白(CRP)、红细胞沉降率(ESR)、血脑利钠肽(BNP)、血清高密度脂蛋白(HDL)和尿乳酸脱氢酶(LDH)等对诊断不完全性川崎病(iKD)的价值。方法选取2007年1月至2008年6月在上海市儿童医院住院治疗的典型川崎病(KD)和iKD患儿各20例。分别于急性期采集样本,除常规测定CRP、ESR外,重点检测血浆BNP、HDL及尿LDH数值。同时选取20名正常儿童作为对照。结果KD患儿年龄总体均数比较差异无统计学意义(P>0.05);血BNP数值总体均数高于对照组,3组间两两比较差异有统计学意义(P均<0.01),且与CRP数值存在线性正相关;血HDL数值总体均数低于对照组,3组间两两比较差异有统计学意义(P均<0.01);尿LDH数值总体均数高于对照组,与对照组比较均P<0.01,差异有统计学意义。结论血BNP、HDL及尿LDH在KD患儿急性期有明显变化,并且具有一定的特异性,有助于iKD患儿急性期的早期诊断。
Objective To investigate the diagnostic value of CRP, ESR, BNP, HDL and LDH in diagnosis of Kawasaki The value of disease (iKD). Methods Twenty patients with typical Kawasaki disease (KD) and iKD inpatients in Shanghai Children’s Hospital from January 2007 to June 2008 were selected. Separately in the acute phase samples were collected, in addition to routine determination of CRP, ESR, the focus of detection of plasma BNP, HDL and urinary LDH values. At the same time select 20 normal children as a control. Results The overall mean age of children with KD had no statistical significance (P> 0.05). The overall mean BNP value of blood was higher than that of the control group (P <0.01) (P <0.01). The total urinary LDH value was higher than that of the control group, which was significantly lower than that of the control group Group P <0.01, the difference was statistically significant. Conclusion Serum BNP, HDL and urinary LDH have obvious changes in the acute stage of children with KD, and have a certain specificity, which is helpful for the early diagnosis of acute stage in children with iKD.