手足口病(HFMD)是一种常见的儿童传染病。我国 HFMD 的流行于1980年始见于上海。随后,河北、山东、北京、天津、吉林、福建、西宁等地均有流行。病原学研究曾表明,CoxA_(16)是我国 HFMD 的病原。日本学者曾发现,日本近年来的HFMD 病原是 CoxA_(16)和 E_(71)型,二者交替流行于日本,1986年～1987年上半年以 E_(71)流行为主,1987年下半年～1988年则以 CoxA_(16)为主。1987年新加坡曾从 HFMD 患者 Hand, foot and mouth disease (HFMD) is a common childhood infection. The epidemic of HFMD in China was first seen in Shanghai in 1980. Subsequently, Hebei, Shandong, Beijing, Tianjin, Jilin, Fujian, Xining and other places are popular. Etiological studies have shown that CoxA_ (16) is the pathogen of HFMD in China. Japanese scholars have found that the pathogens of HFMD in Japan in recent years are CoxA_ (16) and E_ (71). The two are epidemic in Japan. The epidemic of E_ (71) occurred mainly in the first half of 1986 to the first half of 1987, while in the second half of 1987 ~ 1988 is CoxA_ (16) based. Singapore 1987 from HFMD patients