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近几年来,除了不断地报道了关于前列腺素(PG)对胃粘膜的细胞保护作用外,有关上皮生长因子(epidermal growth factor,EGF)对胃粘膜的细胞保护作用已引起了人们的广泛注意。最近,波兰的Konturek等进一步报道了这种作用,并和前列腺素的细胞保护作用作了比较。EGF最初是从雄性小鼠的唾液腺中分离出来的,它是由53个氨基酸组成的多肽,后来又发现它与已发现的尿抑胃素(urogastrone)同是一种物质。Konturek等向大鼠或猫的胃腔中灌注阿斯匹林和盐酸或于胃浅静脉内注入阿斯匹林合并静脉注射组织胺,可造成胃粘膜溃疡。当静脉内或皮下注射EGF后,与给予前列腺素的结果一样,可使用上述方法产生的溃疡的发生率和溃疡面积明显减小。小剂量(1μg/kg)EGF就有
In recent years, besides continuously reporting on the cytoprotective effect of prostaglandin (PG) on gastric mucosa, the protective effect of epidermal growth factor (EGF) on gastric mucosa has drawn extensive attention. More recently, Konturek et al. In Poland reported this effect and compared it with the cytoprotective effect of prostaglandins. EGF, originally isolated from the salivary gland of male mice, was a 53 amino acid peptide that was later found to be identical to the urogastrone that was found. Konturek and other rats or cats to the stomach cavity infusion of aspirin and hydrochloric acid or into the superficial vein intravenous injection of histamine aspirin can cause gastric ulcer. When EGF is injected intravenously or subcutaneously, the incidence of ulceration and the area of ulceration that can be produced using the above methods are significantly reduced, as with the prostaglandin. Low dose (1μg / kg) of EGF there