【摘 要】
：
In the present study,a gastric retention floating system for Bruceajavanica oil,composed of alginate and carrageenan,was prepared using ionotropic gelation.Parameters for floatability,drug load,encapsulation efficiency,bead morphology,in vitro release,and
【机 构】
：
Experiment Center for Teaching and Learning, Shanghai University of Traditional Chinese Medicine, Sh
论文部分内容阅读
In the present study,a gastric retention floating system for Bruceajavanica oil,composed of alginate and carrageenan,was prepared using ionotropic gelation.Parameters for floatability,drug load,encapsulation efficiency,bead morphology,in vitro release,and in vivo gastric retention were evaluated.The optimized formulation via Box-Behnken design consisted of 1.7％ alginate (W/V),1.02％ carrageenan (W/V),1.4％ CaCO3 (W/V),and a gelling bath of pH 0.8.The alginate-carrageenan-Brucea javanica oil beads had a porous structure and exhibited up to 24 h of in vitro floatability with a load capacity of 45％-55％ and an encapsulation efficiency of 70％-80％.A 6-h sustained release was observed in vitro.The beads had a prolonged gastric retention (＞ 60％ at 6 h) in fasted rats,compared to non-floating beads (15％ at 6 h),as measured by gamma scintigraphy with single-photon emission tomography/computed tomography (SPET/CT).In conclusion,the alginate-carrageenan-Bruceajavanica oil system showed enhanced oil encapsulation efficiency,excellent floating and gastric retention abilities,and a favorable release behavior.
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