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抗生素是当今应用最广泛的药物,然而对其与年龄有关的副作用,仍须作进一步的了解。其原因首先是一般不把老年人包括在临床试验中,这至少有一部分是由于大多数老年病人伴有其它疾病,或同时使用其它药物治疗,故不适宜作为药物试验的对象。其次是难以区别是年龄本身的作用,抑或是疾病以及药物治疗的影响。 Caldwell等(1974)报告,使用抗生素治疗的病人,其副作用的发生率为4.4％。在60岁以上的病人中,庆大霉素和卡那霉素引
Antibiotics are the most widely used drugs in the world today, but their age-related side effects need to be further understood. The reason for this is that it is unfit to be the target of the drug test because the elderly are generally not included in the clinical trial at least partly because most elderly patients are accompanied by other diseases or treated with other drugs at the same time. Second, it is difficult to distinguish between the role of age itself, or the impact of disease and drug treatment. Caldwell et al. (1974) reported a 4.4% incidence of side effects in patients treated with antibiotics. In patients over the age of 60, gentamicin and kanamycin cited