近年来对肝性昏迷的病因与发病机制,已有较深入的研究,并提出多种假说。先后报导的“毒性物质”或与之有关的化合物有氨、芳香族氨基酸、短链脂酸、硫醇、γ—氨基丁酸及中分子化合物等。但由于实验的设计、方法,动物模型或所选的病例各不相同,所得结果有很大差异,难以比较。至今尚无较公认的结论。1972年以来,有关人工肝辅助装置的研 In recent years, the etiology and pathogenesis of hepatic coma have been studied in depth and various hypotheses have been proposed. Successively reported “toxic substances” or related compounds are ammonia, aromatic amino acids, short-chain fatty acids, thiols, γ-aminobutyric acid and the medium-molecular compounds. However, due to the experimental design, method, animal model or selected cases vary, the results obtained are very different, it is difficult to compare. So far there is no more generally accepted conclusion. Research on Artificial Liver Assistive Devices since 1972