脑缺血再灌注损伤与细胞凋亡密切相关,细胞凋亡是由基因调控的。研究表明,脑缺血后细胞凋亡的发生是一个主动过程,它依赖于大分子物质合成,说明细胞凋亡是由基因调控的。目前与凋亡相关的基因分为两大类,抗凋亡基因和促凋亡基因。Bcl-2是目前发现的最重要的抗凋亡基因,本文就Bcl-2在脑缺血再灌注损伤中的表达及与缺血性凋亡的关系作一综述。 Cerebral ischemia-reperfusion injury and apoptosis are closely related to apoptosis is gene regulation. Studies have shown that the occurrence of apoptosis after cerebral ischemia is an active process, which relies on the synthesis of macromolecules, indicating that apoptosis is gene regulation. At present, the genes related to apoptosis are divided into two categories, anti-apoptotic genes and pro-apoptotic genes. Bcl-2 is the most important anti-apoptotic gene discovered at present. This article reviews the expression of Bcl-2 in cerebral ischemia-reperfusion injury and its relationship with ischemic apoptosis.