毛果芸香碱被广泛应用于治疗青光眼,此药点眼中毒引起全身反应少见,现报告1例。患者,女,79岁。1992年4月5日,因左眼突然胀痛,头痛,恶心,呕吐就诊。视力眼前20cm手动,诊为急性充血性青光眼。因不愿做手术,带醋氮酰胺片,20％甘露醇溶液和1％毛果芸香碱眼药水回当地治疗。因急欲将散大的瞳孔缩小,在8小时内点用毛果芸香碱眼药水约11ml。虽然眼胀痛,头痛有所减轻,但全身不适、出汗、流涎、气喘、心慌、恶心而来诊求治。血压10.7/6.7kPa,心率118次/分,律整,双肺可闻细小水泡音。眼部检查:左眼视力眼前30cm指动,睫状体血++,角膜雾状混浊,前房浅,约1/5CT,虹膜萎缩,瞳孔中 Pilocarpine is widely used in the treatment of glaucoma, the drug point eye poisoning caused by systemic reactions rare, are reported in 1 case. Patient, female, 79 years old. April 5, 1992, because of sudden left eye pain, headache, nausea, vomiting. Visual acuity 20cm manual, diagnosed with acute congestive glaucoma. Reluctance to surgery, with vinegar azlithium tablets, 20% mannitol solution and 1% pilocarpine eye drops back to the local treatment. Due to the anxious will be dilated pupil narrowing, within 8 hours with pilocarpine eye drops about 11ml. Although the eye pain, headache has been reduced, but the general malaise, sweating, salivation, asthma, palpitation, nausea and seek treatment. Blood pressure 10.7 / 6.7kPa, heart rate 118 beats / min, law, the lungs can smell small blisters sound. Eye examination: the left eye 30cm before moving the eyes, ciliary body blood, corneal haze, anterior chamber shallow, about 1 / 5CT, iris atrophy, in the pupil