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在临床实践中,血清α_1酸性糖蛋白(S-AAG)的检测是作为一种急性相反应物,该物质(分子量为45,000)部分由正常肾脏排泄,故肾功能下降时其值必将增高。然而慢性肾功能衰竭(CRF)时检测 S-AAG是否有诊断价值则不详。作者检测了一组肾功能不全患者和保守或透析治疗的 CRF 终末期患者的 S-AAG水平,发现 CRF 终末期检测 S-AAG 亦有诊断价值。研究对象组Ⅰ为54例不同程度肾功能不全的肾病患者。男29、女25例,年龄18～71岁,血清肌酐(Cr)1.4～20.3mg/dl。患者均未限制饮食,无急、慢性炎症疾病,无肝功能不全及蛋白尿。组Ⅱ为98例
In clinical practice, detection of serum alpha-1 acid glycoprotein (S-AAG) is an acute phase reactant and the substance (molecular weight 45,000) is partially excreted by normal kidneys, so its value is bound to increase when renal function declines. However, the diagnostic value of S-AAG in chronic renal failure (CRF) is unknown. The authors examined S-AAG levels in a subset of patients with CR and end-stage CRF who underwent conservative or dialysis and found that the diagnosis of S-AAG by CRF was also diagnostic. Study group Ⅰ 54 cases of different degrees of renal insufficiency in patients with kidney disease. Male 29, female 25 cases, aged 18 to 71 years, serum creatinine (Cr) 1.4 ~ 20.3mg / dl. Patients were not restricted diet, no acute and chronic inflammatory diseases, liver dysfunction and proteinuria. Group Ⅱ was 98 cases