AIM:Whether operative procedure is a risk factor influencingrecurrence following resection of carcinoma in the head ofpancreas or not remains controversies.In this text wecompared the recurrence rate of two operative procedure:the Whipple procedure and extended radical operation,andinquired into the factors influencing recurrence after radicalresection.METHODS:From January 1995 to December 1998,35 casesof carcinoma of pancreas underwent the Whipple operadure,21 patients received the Extended radical operation.Allpatients were followed up for more than 3 years.Prognosticfactors included operative procedure,size of tumor,lymphnode,interstitial invasion.RESULTS:Deaths duo to recurrence within 3 years afteroperation were studied.The death rate was 51.4% in theWhipple procedure and 42.9% in the Extended radicaloperative procedure.There was a significant differencebetween the two groups.Recurrence occurred in 75%patients with tumor large than 4 cm,in 87.5% patients withlymph node involvement,and in 50% patients with thepresence of interstitial invasion.CONCLUSION:Tumor exceeding 4 cm,lymph nodeinvolvement,and presence of interstitial invasion are highrisk factors of recurrence after Whipple’s procedure andextended radical operation. AIM: Whether operative procedure is a risk factor influencingrecurrence following resection of carcinoma in the head of pancreas or not remains controversies. In this text wecompared the recurrence rate of two operative procedure: the Whipple procedure and extended radical operation, and inquired into the factors influencing recurrence after radical resection. METHODS HODS: From January 1995 to December 1998, 35 cases of carcinoma of pancreas underwent the Whipple operadure, 21 patients received the Extended radical operation. All patients were followed up for more than 3 years. Patients with preoperative examination, size of tumor, lymphnode, interstitial invasion .RESULTS: Deaths duo to recurrence within 3 years afteroperation were studied. The death rate was 51.4% in theWhipple procedure and 42.9% in the Extended radicaloperative procedure. There was a significant differencebetween the two groups. Recurrence occurred in 75% patients with tumor large than 4 cm, in 87.5% patients with lymph node involvement , and in 50% patients with the presence of interstitial invasion. CONCLUSION: Tumor exceeding 4 cm, lymph node invasion, and presence of interstitial invasion are highrisk factors of recurrence after Whipple’s procedure andextended radical operation.