论文部分内容阅读
目的 :制备布比卡因聚乳酸缓释微球 ,并对其体外释药特性进行考察。方法 :以聚乳酸为载体 ,采用 W/O/W乳剂 -扩散溶剂挥发法制备布比卡因聚乳酸缓释微球 ,考察了微球的粉粒学特征 ,并进行了体外溶出研究。 结果 :差热分析表明 ,布比卡因在载体中以分子状态存在 ,与聚乳酸形成了包嵌的微球体 ;其体外释药曲线可用 Higuchi方程拟合 ,t1 /2 =2 2 .76 h。 结论 :布比卡因聚乳酸缓释微球体外具有缓释作用。
OBJECTIVE: To prepare bupivacaine polylactic acid sustained-release microspheres and study its in vitro release characteristics. Methods: The bupivacaine polylactic acid sustained-release microspheres were prepared by W / O / W emulsion-diffusion solvent evaporation method with polylactic acid as the carrier, and the particle characteristics of the microspheres were investigated. The dissolution in vitro was also studied. Results: Differential thermal analysis showed that bupivacaine existed in molecular state in the carrier and formed inclusion microspheres with polylactic acid. The in vitro release curves of bupivacaine were fitted by Higuchi equation with t1 / 2 = 2.27 h . Conclusion: Bupivacaine PLA sustained-release microspheres have sustained release in vitro.