中期妊娠妇女血中甲胎蛋白升高,可以用来诊断胎儿异常。母体血浆甲胎蛋白(AFP)的测定主要用来早期发现胎儿神经管缺陷,其次见于多胎,宫内死亡,自然流产、产期死亡、低体重儿及先天性畸形如脐疝、Finnish 肾病综合征。本文报导了15,481例妊娠15—22周妇女的 AFP 测定经验。作者对四所医院的全部孕妇进行血浆 AFP 的测定,作为胎儿神经管缺陷的一种筛选 A fetoprotein in the blood of mid-term pregnant women can be used to diagnose fetal abnormalities. Maternal plasma alpha-fetoprotein (AFP) was mainly used to detect early fetal neural tube defects, followed by multiple births, intrauterine death, spontaneous abortion, maternal death, low birth weight infants and congenital malformations such as umbilical hernia, Finnish nephrotic syndrome . This article reports on AFP assaying experience in 15,481 women 15-22 weeks of gestation. The authors performed a plasma AFP assay on all pregnant women in four hospitals as a screening for fetal neural tube defects