随着白三烯及其埘肺组织强有力作用的发现,人们不再重视肺生理或病理过程中天然产生的前列腺素(PG)和血栓素 A_2(TXA_2)之潜在作用。本文以较新的观点来重新认识它们的可能作用。【生物化学】第二族 PG 和 TXA_2由细胞膜磷脂中的花生四烯酸(AA)形成。AA 借磷脂酶 A_2和 C 作用而释放,并通过环氧酶作用转变成环内过氧化物,后者进一步经酶和非酶步骤形成 PG 和TX_2。环氧酶也可利用不饱和脂肪酸二后莫 With the strong role of leukotrienes and their lungs, people no longer value the potential role of naturally occurring prostaglandins (PGs) and thromboxane A_2 (TXA_2) in the lung physiology or pathology. This article revisits their possible role with newer perspectives. Biochemistry Group 2 PG and TXA 2 are formed from arachidonic acid (AA) in cell membrane phospholipids. AA is released by the action of phospholipases A_2 and C and is converted to cyclic peroxides by the action of cyclooxygenase, which further forms PG and TX_2 by enzymatic and non-enzymatic steps. Epoxidase can also use unsaturated fatty acid two Mo