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目的:了解住院精神分裂症患者药物治疗情况的年代变迁.方法:采用回顾性研究设计,从三所精神卫生专科医院分层随机抽取不同年代住院精神分裂症患者的病历资料,登记药物治疗情况和相关资料.结果:不同年代间单一用药比例无显著改变(P<0.05),但联合用药方案有显著差异(P<0.01),其中1980年代以FGA+FGA联用为主,1990年代以SGA+FGA联用为主,2000年代以SGA+FGA和SGA+SGA为主;不同年代间合并用药种类存在显著差异(P0.05)、时点最高剂量存在差异(P0.05) on the antipsychotic mono-therapy rate across decades,but the antipsychotic combination pattern was significantly different(P<0.05) across decades.Most common antipsychotic polypharmacy was FGAs+SGAs in 1980ss,FGAs+SGAs in 1990ss,FGAs+SGAs and SGAs+SGAs in 2000s.Moreover,there was statistically significant difference(P0.05) for the stable therapeutic dosage,and there was significant difference for the highest time dosage(P<0.05) across years.Conclusion: The antipsychotic polypharmacy and comedication pattern have changed over the last three decades,at the same time,the using rates of SGAs,antianxiety agents and anticonvulsants are increasing,and the highest time dose is declining.