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为了研究菖龙丹 (CLD)对衰老小鼠脑内氨基酸类神经递质和锌的影响 ,阐明CLD抗老年性痴呆作用与氨基酸类神经递质的关系。以老年小鼠 (13月龄 )为实验对象 ,灌胃给予CLD和吡拉西坦 (Pir) ,连续 81d。采用高效液相色谱法测定脑组织中谷氨基 (Glu)、天冬酸 (Asp)和r 氨基丁酸 (GABA)含量 ,以原子吸收分光光度法测定脑组织Zn含量。结果 :老年小鼠脑组织Glu、Asp、GABA的含量均显著降低 (P <0 .0 1) ,CLD和Pir可提高老年小鼠脑组织Glu、GABA含量 (P <0 .0 5和P <0 .0 1) ,CLD和Pir二者相比差异无显著性意义 (P >0 .0 5 )。CLD还可使脑组织中Zn含量明显升高 (P <0 .0 5 )。结论 :CLD可升高衰老小鼠脑内Glu、GABA、Zn含量 ,其改善记忆功能与其对脑内氨基酸类神经递质的调节作用等有关。
In order to study the effect of CLD on amino acid neurotransmitters and zinc in the brain of aging mice, the relationship between CLD’s effect on senile dementia and amino acid neurotransmitters was elucidated. The aged mice (13 months old) were given intragastric administration of CLD and piracetam (Pir) for 81 days. The contents of glutamic acid (Glu), aspartic acid (Asp) and aminobutyric acid (GABA) in brain tissue were determined by high performance liquid chromatography. The content of Zn in brain tissue was determined by atomic absorption spectrophotometry. Results: The contents of Glu, Asp, and GABA in the brain of aged mice were significantly decreased (P < 0.01). CLD and Pir increased the content of Glu and GABA in brain tissue of aged mice (P <0.05 and P <0.05). 0 .0 1) , CLD and Pir were not significantly different (P > 0.05). CLD also increased the Zn content in brain tissue (P < 0.05). Conclusion : CLD can increase the content of Glu, GABA and Zn in the brain of aging mice. It is related to the improvement of memory function and its regulation of amino acid neurotransmitters in the brain.