论文部分内容阅读
目的探讨磷酸神经鞘氨醇(S1P)在胃癌组织中的表达及其临床意义。方法采用实时荧光定量PCR和免疫组织化学染色检测60例胃癌组织及其癌旁正常胃黏膜组织中S1P和S1P受体1(S1PR1)的表达,分析血清S1P表达与胃癌患者预后的关系。结果 S1P和S1PR1在胃癌组织中的表达均高于癌旁正常胃黏膜组织(P<0.01)。S1P表达与S1PR1和IL-6表达均呈正相关(r=0.304和0.241,P<0.01)。胃癌患者血清S1P的表达与术后累积生存率呈负相关(HR=2.246,P<0.01)。结论 S1P在胃癌组织中高表达,在胃癌进展中发挥重要作用,有望成为胃癌预后判断和治疗的新靶点。
Objective To investigate the expression of sphingosine phosphate (SphP) in gastric carcinoma and its clinical significance. Methods The expressions of S1P and S1P receptor 1 (S1PR1) in 60 gastric cancer tissues and normal gastric mucosa tissues were detected by real-time fluorescence quantitative PCR and immunohistochemical staining. The relationship between S1P expression and the prognosis of gastric cancer patients was analyzed. Results The expressions of S1P and S1PR1 in gastric cancer tissue were significantly higher than those in normal gastric mucosa (P <0.01). S1P expression was positively correlated with S1PR1 and IL-6 expression (r = 0.304 and 0.241, P <0.01). The expression of S1P in gastric cancer patients was negatively correlated with the postoperative cumulative survival rate (HR = 2.246, P <0.01). Conclusion S1P is highly expressed in gastric cancer tissues and plays an important role in the progression of gastric cancer, which may be a new target for the prognosis and treatment of gastric cancer.