帕金森病是一种常见的神经系统变性疾病,其发病机制至今不甚明了。流行病学调查发现,吸烟与帕金森病发病之间存在负相关,提示烟碱系统可能与PD关系密切。本文首先阐述了烟碱受体不同亚基在中枢神经系统的分布、功能及与黑质纹状体损害的关系。进而论述了烟碱对PD的症状改善作用,及其通过抑制氧化应激、促进DA的释放、诱导神经营养因子表达等机制而发挥的神经保护作用。 Parkinson’s disease is a common degenerative disease of the nervous system, the pathogenesis has so far not clear. Epidemiological survey found that there is a negative correlation between smoking and the incidence of Parkinson’s disease, suggesting that the nicotinic system may be closely related to PD. This article first described the distribution of nicotinic receptor subunits in the central nervous system, function and the relationship between nigrostriatal damage. Furthermore, the effect of nicotine on the improvement of PD symptoms and its neuroprotective effect by inhibiting oxidative stress, promoting the release of DA and inducing the expression of neurotrophic factor were discussed.