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目的探讨卡前列素氨丁三醇联合缩宫素在高危妊娠剖宫产术后产后出血的防治效果。方法 100例实施剖宫产术的高危妊娠产妇,随机分为联合用药组和单用缩宫素组,每组50例。联合用药组给予卡前列素氨丁三醇联合缩宫素进行防治,单用缩宫素组给予缩宫素进行防治。观察两组剖宫产术后2 h和2~24 h的出血量、出血发生率、输血发生率及应用附加止血措施发生率及不良反应发生情况。结果联合用药组剖宫产术后2 h、2~24 h出血量分别为(94.5±12.9)、(61.5±13.8)ml,单用缩宫素组剖宫产术后2 h、2~24 h出血量分别为(158.3±20.3)、(85.1±15.2)ml,联合用药组剖宫产术后2 h出血量和术后2~24 h出血量均低于单用缩宫素组,差异有统计学意义(P<0.05);联合用药组产后出血发生率12.0%、输血发生率4.0%、应用附加止血措施发生率8.0%分别低于单用缩宫素组的30.0%、24.0%、26.0%(P<0.05);联合用药组不良反应发生率为12.0%,单用缩宫素组不良反应发生率为8.0%,比较差异无统计学意义(P>0.05)。结论以缩宫素为基础联合应用卡前列素氨丁三醇防治高危妊娠剖宫产术后产后出血临床效果显著,值得临床借鉴应用。
Objective To investigate the prevention and treatment of postpartum hemorrhage with cetuximab and oxytocin combined with oxytocin after cesarean section in high-risk pregnancies. Methods 100 cases of high risk pregnant women who underwent cesarean section were randomly divided into combination group and oxytocin group, with 50 cases in each group. Combined treatment group was given carboprost trometamol combined with oxytocin for prevention and treatment, oxytocin alone with oxytocin for prevention and treatment. The incidences of bleeding, the incidence of bleeding, the incidence of transfusion and the incidence of adverse reactions were observed at 2 h and 2-24 h after cesarean section in both groups. Results The bleeding volume at 2 h and 2 ~ 24 h after cesarean section in the combination group was (94.5 ± 12.9) and (61.5 ± 13.8) ml, respectively. The oxytocin group at 2 h and 2 ~ 24 h after cesarean section h were (158.3 ± 20.3) and (85.1 ± 15.2) ml, respectively. The bleeding volume at 2 h after cesarean section and the bleeding volume at 2 ~ 24 h after cesarean section in combination group were all lower than those in oxytocin group (P <0.05). The incidence of postpartum hemorrhage and the incidence of blood transfusion in combination group were 12.0% and 4.0% respectively, and the incidence of postoperative bleeding was 8.0% and 30.0% respectively compared with that of oxytocin alone group and 24.0% The incidence of adverse reactions was 12.0% in the combination group and 8.0% in the oxytocin group alone, with no significant difference (P> 0.05). Conclusions The combination of oxytocin and carbostyril trometamol in the prevention and treatment of postpartum hemorrhage after cesarean section of high-risk pregnancy clinical effect is significant, it is worth learning from the clinical application.