Bcl-2家族促凋亡蛋白Bim在骨改建中的作用及调节

来源 :医学综述 | 被引量 : 0次 | 上传用户：q344494

【摘要】

：

骨改建是由骨吸收与骨形成精密控制的生理过程,其中破骨细胞、成骨细胞分别是骨吸收、骨形成的功能细胞.生理状态下成骨细胞形成新骨与破骨细胞吸收旧骨处于平衡稳定状态,病

【作者】

：

宋祥晨

【机构】

：

中山大学光华口腔医学院附属口腔医院牙周病科广东省口腔医学重点实验室

【出处】

：

医学综述

【发表日期】

：

2004年期

【关键词】

：

Bim 成骨细胞破骨细胞骨改建 Bim Osteoblast Osteoclast Bone remolding

【基金项目】

：

留学归国人员科研启动基金;国家自然科学基金;广东省科技计划项目

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论文部分内容阅读

骨改建是由骨吸收与骨形成精密控制的生理过程,其中破骨细胞、成骨细胞分别是骨吸收、骨形成的功能细胞.生理状态下成骨细胞形成新骨与破骨细胞吸收旧骨处于平衡稳定状态,病理状态下成骨细胞和(或)破骨细胞的凋亡异常影响骨改建.Bcl-2 interacting mediator of cell death(Bim)作为内在凋亡通路上Bcl-2家族促凋亡蛋白,在骨改建中发挥重要作用.该文就Bim在成骨细胞及破骨细胞凋亡过程中表达、调节及骨改建中的作用予以综述.

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Bcl-2家族促凋亡蛋白Bim在骨改建中的作用及调节

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