目的观察小剂量静脉滴注甲基强的松龙联合吸入高剂量布地奈德对儿童哮喘急性发作的治疗效果。方法将46例哮喘急性发作患儿随机分为试验组和观察组各23例,其中观察组给予静滴地塞米松,2次/d,雾化吸沙丁胺醇,3次/d。试验组给予甲基强的松龙静滴,1次/8 h;雾化吸沙丁胺醇和布地奈德,3次/d,观察两组临床疗效及不良反应。结果经过比较发现治疗后7 d试验组PEFam;PEFpm;FEV1;FEV1/FVC(%)改善情况治疗组明显优于观察组,差异有统计学意义(P<0.05),并且日间哮喘症状评分,夜间哮喘症状评分、明显低于对照组,治疗后7 d和14 d试验组临床计分改善情况明显优于对照组,差异有统计学意义(P<0.05),两组均未见明显的不良反应。结论小剂量甲基强的松龙联合高剂量雾化吸入布地奈德治疗儿童哮喘急性发作,疗效显著,值得在临床推广。 Objective To observe the therapeutic effect of low-dose intravenous methylprednisolone and inhaled high-dose budesonide on acute asthma in children. Methods A total of 46 children with acute asthma attack were randomly divided into experimental group and observation group (n = 23). The observation group was treated with intravenous dexamethasone twice a day for salbutamol inhalation 3 times a day. The experimental group was given intravenous infusion of methylprednisolone, once / 8 h; inhalation of salbutamol and budesonide inhalation, 3 times / d, the clinical efficacy and adverse reactions were observed in both groups. Results After treatment, the improvement of PEFam; PEFpm; FEV1; FEV1 / FVC (%) in experimental group was significantly better than that of observation group on the 7th day after treatment, the difference was statistically significant (P <0.05) Night asthma symptom score was significantly lower than the control group, 7 d and 14 d after treatment, the clinical score improved significantly better than the control group, the difference was statistically significant (P <0.05), no significant difference between the two groups reaction. Conclusion Small doses of methylprednisolone combined with high-dose inhalation of budesonide in the treatment of acute asthma in children has a significant curative effect and is worthy of clinical application.