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本文依据群体药动学参数和丁胺卡那霉素的消除特点,建立了一种预测丁胺卡那霉素个体化给药方案的方法。临床应用结果表明,20例病人预测的个体化剂量为6.3±0.8mg/kg,预测的峰、谷浓度分别为 22.97±2.20mg/L和 3.75±2.13mg/L,与临床监测结果 23.70±3.49mg/L和 3.24±2.05mg/L非常接近(P>0.05)。药动学参数预测值为,CL86.5±31.6ml·h~(-1)·kg~(-1),V_d0.2488±0.0026L/kg,T_(1/2)2.19±0.62h;与实际值CL89.3±37.lml·h~(-1)·kg~(-1),V_d0.2412±0.0695L/kg,T_(1/2)2.18±1.23h比较,差异均无显著意义(P>0.05)。
Based on the population pharmacokinetic parameters and the elimination characteristics of amikacin, a method to predict the individualized administration of amikacin was established. The results of clinical application showed that the individualized dose predicted by 20 patients was 6.3 ± 0.8mg / kg, the predicted peak and trough concentrations were 22.97 ± 2.20mg / L and 3.75 ± 2.13mg / L, respectively, which were in good agreement with the clinical monitoring results of 23.70 ± 3.49 mg / L and 3.24 ± 2.05 mg / L were very close (P> 0.05). The predicted pharmacokinetic parameters were CL86.5 ± 31.6ml · h -1 · kg -1, V_d0.2488 ± 0.0026L / kg and T 1/2 (1/2) 2.19 ± 0.62h. The actual values of CL89.3 ± 37.lml · h -1 · kg -1, V_d0.2412 ± 0.0695L / kg and T 1/2 of 2.18 ± 1.23h showed no significant difference (P> 0.05).