论文部分内容阅读
目的 研究C反应蛋白(CRP)、氧化型低密度脂蛋白自身抗体(anti-oxLDL)与冠心病斑块稳定性的关系。方法 2003-07～12第一军医大学南方医院分别测定21例急性心肌梗死(AMI)、22例不稳定型心绞痛(UAP)、20例稳定型心绞痛(SAP)和21例对照者的CRP、oxLDL自身抗体和LDL自身抗体水平,比较各组中上述指标有无显著差异,并评估CRP分别与两种抗体水平的相关性。结果 急性冠状动脉综合征(ACS)组(包括AMI组和UAP组)的CRP明显高于SAP组和对照组(P<0.05);ACS组的oxLDL自身抗体水平明显高于SAP组和对照组(P<0.05);各组LDL自身抗体水平比较无显著差异(P>0.05);各组中CRP与oxLDL自身抗体水平是显著正相关(P<0.01),CRP与LDL自身抗体水平无显著相关性(P>0.05)。结论 对特异性抗原oxLDL的免疫反应,在导致斑块的不稳定及急性冠状动脉综合征的发生中可能起着重要的作用,oxLDL自身抗体水平可能是评价CHD斑块不稳定的重要特异性标志物。
Objective To study the relationship between C-reactive protein (CRP) and oxidized low density lipoprotein (anti-oxLDL) and plaque stability. Methods Twenty-one patients with acute myocardial infarction (AMI), 22 patients with unstable angina pectoris (UAP), 20 patients with stable angina pectoris (SAP) and 21 controls were studied in Southern Hospital of First Military Medical University from July 2003 to December 12, 2003. Autoantibodies and LDL autoantibodies, comparing the above indicators in each group was no significant difference, and to assess the CRP respectively with the two antibody levels. Results The CRP of ACS group (including AMI group and UAP group) was significantly higher than that of SAP group and control group (P <0.05). The level of oxLDL autoantibody in ACS group was significantly higher than that in SAP group and control group (P <0.05). There was no significant difference in the levels of autoantibodies against LDL between the two groups (P> 0.05). There was a significant positive correlation between CRP and oxLDL autoantibodies in each group (P <0.01), and there was no significant correlation between CRP and LDL autoantibodies (P> 0.05). Conclusion The immune response to specific antigen oxLDL may play an important role in causing plaque instability and the occurrence of acute coronary syndrome. The level of oxLDL autoantibody may be an important specific marker for evaluating the plaque instability of CHD Things.