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ACE抑制剂引起的咳嗽为持续性干咳,通常有咽喉部刺激感,特别是卧位时加重,常可影响睡眠。此种副作用一般于服药开始后数用至数月发生,但也有初次服药后数小时即发生的病例。如果停止给药,咳嗽通常于数日内消失,据Coulter统计,平均停用甲巯丙脯酸后3.4天;苯脂丙脯酸5.5天后咳嗽消失,如果再使用ACE抑制剂可于数小时内复发。本文就此种副作用的有关问题加以叙述。1.发病率ACE抑制剂所致的咳嗽发病率各家报道不一,甲巯丙脯酸为0.25～25%,苯脂丙脯酸为1.0～33%,而其他ACE抑制剂的发病率尚未进行大规模调查。多数报道,苯脂丙脯酸的发病率较甲巯丙脯酸高。这些药物致咳嗽发病率不同除各药物在其所分布组织中吸收、脱酯化及组织渗透性等药物动力
Cough caused by ACE inhibitors is a persistent dry cough, often with a sense of throat irritation, especially when lying decubitus, often affecting sleep. Such side effects generally take several months to several months after the start of the medication, but there are also cases that occur hours after the first dose. Cough usually disappears in a few days if cessation of administration, according to Coulter statistics, averaging 3.4 days after captopril discontinuation; cough disappeared after 5.5 days of phenylephrine, and recurred within hours if ACE inhibitors were reused . This article describes the related issues of such side effects. 1. Morbidity The incidence of cough caused by ACE inhibitors varies from person to person, with captopril 0.25 to 25% and phenibiprown 1.0 to 33%, whereas the incidence of other ACE inhibitors has not yet been reported Conduct a large-scale survey. Most reported that the incidence of phenyiprol is higher than that of captopril. These drugs cause different incidence of cough in addition to the drugs in the distribution of their absorption, deesterification and tissue permeability and other pharmacodynamic