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哌拉西林(PIPC)对革兰氏阳性菌,特别是对革兰氏阴性菌的绿脓杆菌、变形菌、肺炎杆菌、沙雷氏菌等具有良好的抗菌作用。作者试用PIPC治疗以急性白血病为主的小儿恶性肿瘤合并感染症55例,对其疗效进行了探讨。给药方法PIPC 136～323mg/kg·d,分3～4次静滴,在30分钟内滴完。联用药剂有头孢菌素(头孢替安、Latamoxef、头孢匹林、头孢美唑、Cefpiramide、头孢唑肟等)、氨基糖苷类抗生素(庆大霉素、丁胺卡那霉素)等,有些病例联用γ-球蛋白制剂。受试对象年龄从8个月至15岁,平均8岁。男31例,女24例。基础疾病急性淋巴性白血病13例,急性非淋巴性白血病28例,恶性淋巴肿瘤5例,其他肿瘤9例。感染症败血症3例,病灶不明的感染
Piperacillin (PIPC) against Gram-positive bacteria, especially against Gram-negative bacteria Pseudomonas aeruginosa, Proteus, Klebsiella pneumoniae, Serratia has a good antibacterial effect. The author tried PIPC treatment of 55 cases of acute leukemia-based combined infection of children with malignant tumors, and its efficacy were discussed. Administration PIPC 136 ~ 323mg / kg · d, intravenous infusion of 3 to 4 drops over 30 minutes. In combination with cephalosporins (cefotiam, Latamoxef, cefpirome, cefmetazole, Cefpiramide, ceftizoxime, etc.), aminoglycoside antibiotics (gentamicin, amikacin) Cases with γ-globulin preparations. Subjects from 8 months to 15 years old, with an average of 8 years old. 31 males and 24 females. 13 cases of acute lymphoblastic leukemia, 28 cases of acute non-lymphoid leukemia, 5 cases of malignant lymphoma and 9 cases of other tumors. Infectious septicemia in 3 cases, unknown lesions