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目的探讨人血管紧张素转换酶(ACE)基因插入/缺失多态性(I/D)与新诊断2型糖尿病(T2DM)患者颈总动脉内中膜厚度(CCA-IMT)的关系。方法采用限制性片段长度多态性-聚合酶链反应(PCR-RFLP)技术,检测2005年5月至2006年5月东莞市人民医院内分泌门诊收治的120例T2DM患者ACE基因内含子16I/D多态性,利用B超检测其CCA-IMT,通过多元Logistic回归分析筛选T2DM患者CCA-IMT增厚的危险因素。结果携带ACE基因DD型者CCA-IMT增厚的比例显著高于携带II及ID基因型者(F=10.164,P=0.006);Logistic回归分析显示,ACEDD基因型、年龄、合并高血压是T2DM患者CCA-IMT增厚的危险因素(OR分别为3.689,1.054,1.562,P均<0.05)。结论ACEDD基因型是T2DM患者CCA-IMT增厚的独立危险因素。
Objective To investigate the relationship between the insertion / deletion polymorphism of human angiotensin converting enzyme (ACE) gene and intima - media thickness (CCA - IMT) in patients with newly diagnosed type 2 diabetes mellitus (T2DM). Methods A total of 120 cases of T2DM patients with endometriosis admitted from May 2005 to May 2006 in Dongguan Diabetes Hospital were enrolled in this study. The intron 16I / D polymorphism. The CCA-IMT was detected by B-ultrasound. The risk factors of CCA-IMT thickened in T2DM patients were screened by multivariate Logistic regression analysis. Results The proportion of CCA-IMT patients with ACE genotype DD was significantly higher than those with II and ID genotypes (F = 10.164, P = 0.006). Logistic regression analysis showed that ACEDD genotype, age, and hypertension were T2DM Patients with CCA-IMT thickening risk factors (OR were 3.689,1.054,1.562, P all <0.05). Conclusion The ACEDD genotype is an independent risk factor for CCA-IMT thickening in T2DM patients.