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结合光学相干层析技术的三维成像能力和动态散射技术的运动识别能力,可以实现无标记的三维光学微血管造影,在不牺牲线扫描速度的前提下,通过帧间分析的方法提高血流造影的灵敏度,实现毛细血管水平的探测.提出小波域分量复合的方法降低静态组织信号和动态血流信号之间的分割误差,实现高对比度的血管造影分别利用组织血流模拟样品和活体大鼠脑组织进行实验验证,结果发现,采用小波域分量复合之后,血管分割误差分别减小了83%和71%,造影图对比度增强,并且具有更好的血管连接性.进而,利用研制的系统对大鼠脑血管局部缺血性中风模型进行了初步的成像研究,清晰地呈现了中风模型形成,血管受损和血管恢复的整个过程,有助于对局部缺血性中风模型机理的研究.
Combined with the three-dimensional imaging ability of optical coherence tomography and the kinematic recognition ability of dynamic scattering technology, it is possible to realize mark-free three-dimensional optical microangiography and improve the contrast of blood flow by means of inter-frame analysis without sacrificing the line scanning speed Sensitivity and realize the detection of capillary level.Wavelet domain component synthesis method is proposed to reduce the segmentation error between static tissue signal and dynamic blood flow signal to achieve high contrast angiography using tissue flow simulation sample and living rat brain tissue The experimental results show that the segmentation error is reduced by 83% and 71%, respectively, and the contrastive contrast enhancement is better, and the vascular connectivity is better.With the developed system, A preliminary imaging study of cerebrovascular ischemic stroke model clearly shows the whole process of stroke model formation, vascular damage and blood vessel recovery, which is helpful for the study of the mechanism of ischemic stroke model.