论文部分内容阅读
目的探讨铜绿假单胞菌临床分离株的感染分布情况及其抗生素的耐药情况,指导临床合理用药。方法对我院2006年1月至2008年6月住院患者分离的铜绿假单胞菌进行抗生素敏感性测定,采用API系统及VITEK2系统进行细菌鉴定,用K-B法进行药敏试验及结果观察。结果216例院内感染铜绿假单胞菌病例中,从痰标本中分离的菌株最多,阳性率为45.4%;铜绿假单胞菌对头孢噻肟、复方新诺明、头孢哌酮的耐药率较高,分别为88%、86.1%和85.2%,对美洛培南的敏感性最高达到94%。结论铜绿假单胞菌是医院病原菌感染的主要致病菌之一,加强细菌和药敏监测,选择敏感性强的药物,避免广谱抗菌药物的长期应用,是延缓耐药菌株增加的有效办法。
Objective To investigate the infection distribution of Pseudomonas aeruginosa clinical isolates and their antibiotic resistance and to guide clinical rational drug use. Methods The antibiotic susceptibility of Pseudomonas aeruginosa isolated from hospitalized patients from January 2006 to June 2008 in our hospital was determined. The bacteria were identified by API system and VITEK2 system. The susceptibility test and results were observed by K-B method. Results Among the 216 cases of nosocomial P. aeruginosa, the most isolates were isolated from sputum samples, the positive rate was 45.4%. The resistance rate of P. aeruginosa to cefotaxime, cotrimoxazole and cefoperazone was the highest Were higher, 88%, 86.1% and 85.2% respectively, with the highest sensitivity to meropenem reaching 94%. Conclusion Pseudomonas aeruginosa is one of the main pathogenic bacteria in hospital pathogen infection. It is an effective way to delay the increase of resistant strains by strengthening the monitoring of bacteria and drug susceptibility, selecting the sensitive drugs and avoiding the long-term application of broad-spectrum antimicrobial drugs .