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白细胞介素12（IL－12）是异二聚体细胞因子（CK），主要由抗原递呈细胞（APCs）产生，在介导对原虫、胞内菌、真菌、病毒等病原的细胞免疫中起主要作用，其作用包括：诱导静止及活化的天然杀伤细胞（NK）及T细胞产生γ干扰素（γ－IFN）；促进NK及T细胞的增殖；增强NK的细胞毒作用；促使细胞毒T淋巴细胞（CTL）的成熟。IL－12是感。染性疾病的早期先天免疫及后期特异免疫的桥梁，它的产生在CK网络中受到正负反馈机制的调节。宿主防御各种感染的过程中，IL－12起保护作用的同时于某些疾病状态下也有不利作用。因此，IL－12很有希望应用于适当条件下各种人类感染性疾病的防治。
Interleukin 12 (IL-12) is a heterodimeric cytokine (CK) that is produced mainly by antigen presenting cells (APCs) and is involved in the cellular immunity mediated by protozoa, intracellular bacteria, fungi, viruses and other pathogens Play a major role, its role includes: induction of static and activated natural killer cells (NK) and T cells produce gamma interferon (γ-IFN); promote the proliferation of NK and T cells; enhance the cytotoxicity of NK; to promote cytotoxicity T lymphocyte (CTL) maturation. IL-12 is a feeling. Dye disease early innate immunity and late-specific immune bridge, its production in the CK network by positive and negative feedback mechanism of regulation. In the course of host defense against various infections, IL-12 also plays a protective role and also has adverse effects in certain disease states. Therefore, IL-12 is promising for the prevention and treatment of various human infectious diseases under appropriate conditions.