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[背景]假设随着年龄的增长,空气污染和肥胖通过致炎特性加速肺功能减退。[目的]先前公布的以人口为基础的SAPALDIA队列研究中,空气质量改善与肺部健康之间是否存在关联。本文探讨肥胖是否会改变这一关联。[方法]使用校正的混合模型分析,评估在10年的随访期间,平均身体质量指数(BMI)和空气动力学直径≤10μm的颗粒物变化(PM10;ΔPM10)与肺功能减退之间的关联。[结果]共获得4664人的肺功能数据和完整信息。与低或正常平均BMI者相比,高平均BMI者年龄相关的肺功能减退,其FVC(用力肺活量)指标下降得更快,而FEV1/FVC(1秒用力呼气量/FVC)和FEF25-75(在25%～75%肺活量时的用力呼气流量)下降的速度较慢。在低和正常BMI者中,空气质量改善与随着时间推移的FEV1/FVC、FEF25-75、FEF25-75/FVC下降减缓相关,但在超重或肥胖者中无相关性。这种减缓作用在ΔFEF25-75/FVC上最为明显:在低或正常体质量者中,PM10每下降10μg/m3,ΔFEF25-75/FVC下降分别为30%和22%。[结论]上述研究结果指出并列考虑空气污染暴露和肥胖对健康的影响的重要性。今后需要进一步研究所观察到的相互作用的机制。
[Background] Assuming that as timegoles, air pollution and obesity accelerate lung hypofunction through pro-inflammatory properties. [Purpose] In the previously published population-based SAPALDIA cohort study, whether there was a correlation between air quality improvement and lung health. This article explores whether obesity can change this link. [Method] Corrected mixed model analysis was used to assess the association between changes in mean body mass index (BMI) and aerosol particle size ≤10 μm (PM10; ΔPM10) and hypofunction during a 10-year follow-up period. [Results] A total of 4664 lung function data and complete information were obtained. Compared with low or normal mean BMI, age-related lung dysfunction with a high mean BMI decreased more rapidly with FVC (forced vital capacity), whereas FEV1 / FVC (1 second forced expiratory volume / FVC) and FEF25- 75 (forced expiratory flow at 25% to 75% of vital capacity) decreased more slowly. In both low and normal BMI, improvements in air quality correlate with the slowing down of FEV1 / FVC, FEF25-75, FEF25-75 / FVC over time, but not in overweight or obese subjects. This mitigation effect is most pronounced on ΔFEF25-75 / FVC: 10 μg / m3 drop for PM10 and 30% and 22% decrease for ΔFEF25-75 / FVC for low and normal body mass, respectively. [Conclusions] The above results indicate the importance of considering the health effects of air pollution exposure and obesity side by side. Future studies will need to further examine the observed mechanisms of interaction.