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1975年美国芝加哥伊利诺大学的Drill教授概括了100多篇关于雌激素和口服避孕药能否致癌的文章,认为雌激素和口服避孕药,不论在实验动物或人体中,都不会引起乳腺癌和子宫颈癌。但是,近几年来,越来越多的研究表明,雌激素有诱发癌变的危险性。Berenblum提出,雌激素可刺激子宫内膜的敏感组织,导致癌变;刺激时间越长,癌的发病率越高。美国加利福尼亚大学的一些学者指出,绝经后的妇女若长期使用雌激素治疗,有促发乳腺癌的危险性。服用大剂量的雌激素(口服1.25mg,三年)的妇女,其乳腺癌发病率为对照组的2.5倍。
Professor Drill from the University of Illinois at Chicago in 1975 summarized more than 100 articles on whether estrogen and oral contraceptives can cause cancer. He concluded that estrogen and oral contraceptives will not cause breast cancer in experimental animals or in humans And cervical cancer. However, in recent years, more and more studies have shown that estrogen has the risk of carcinogenesis. Berenblum proposed that estrogen can stimulate the sensitive endometrial tissue, leading to cancer; the longer the stimulus, the higher the incidence of cancer. Some scholars at the University of California, the United States pointed out that if women after postmenopausal long-term use of estrogen therapy, there is the risk of breast cancer. Women who took large doses of estrogen (1.25 mg orally for three years) had a 2.5-fold higher incidence of breast cancer than the control group.