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目的:观察丹参酮ⅡA磺酸钠联合低分子肝素治疗不稳定性心绞痛的临床疗效。方法:采用对照研究,经患者知情同意,采用随机分配的方法,分为治疗组和对照组60例。对照组采用常规治疗,治疗组在对照组治疗的基础上,加用低分子肝素钙+丹参酮ⅡA磺酸钠。两组用药前后观察临床症状、心电图、出血时间、凝血时间、凝血酶原时间,通过分析比较各项指标,判断疗效。结果:治疗组心电图有效率高于对照组(P<0.05);治疗组临床总有效率为88.33%,对照组为65.00%,治疗组疗效高于对照组(P<0.05),治疗组凝血3项指标(出血时间、凝血时间、凝血酶原时间)治疗前后无明显变化,对照组变化明显(P<0.05)。结论:常规治疗上加用低分子肝素钙+丹参酮ⅡA磺酸钠治疗不稳定性心绞痛的治疗效确切且安全可靠。
Objective: To observe the clinical efficacy of sodium tanshinone Ⅱ A sulfonate combined with low molecular weight heparin in the treatment of unstable angina pectoris. Methods: A controlled study, informed consent by patients, using random allocation method, divided into treatment group and control group of 60 patients. The control group with conventional treatment, the treatment group in the control group based on the treatment, plus low molecular weight heparin + tanshinone Ⅱ A sodium sulfonate. Clinical symptoms, electrocardiogram, bleeding time, clotting time and prothrombin time were observed before and after treatment in both groups to determine the therapeutic effect by analyzing and comparing various indexes. Results: The effective rate of electrocardiogram in the treatment group was higher than that of the control group (P <0.05). The total clinical effective rate was 88.33% in the treatment group and 65.00% in the control group, and the curative effect in the treatment group was higher than that in the control group (P <0.05) Indicators (bleeding time, clotting time, prothrombin time) before and after treatment did not change significantly in the control group changed significantly (P <0.05). Conclusion: The treatment of unstable angina with low molecular weight heparin + sodium tanshinone Ⅱ A in conventional therapy is effective and safe.