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①目的 观察高糖摄入对正常Ｓｐｒａｇｕｅ－Ｄａｗｌｅｙ（ＳＤ）大鼠血压、糖及胰岛素代谢的影响。②方法将雄性ＳＤ大鼠１６只随机分为２组，实验组于饮水中添加蔗糖（１２０ｇ／Ｌ）喂养４２ｄ，对照组给以正常饮水，每７ｄ 定时测量体质量（ＢＷ）、收缩压（ＳＢＰ）及心率（ＨＲ），实验最后１ｄ 取血测定空腹血糖（ＦＢＧ）和血清胰岛素（ＩＮＳ）等。③结果 自第８ 天起，实验组ＳＢＰ及ＨＲ即高于对照组，并持续至实验结束（ｔ＝ ２．１８～５．６０，Ｐ均＜ ０．０５，０．０１）；与对照组相比，实验组ＦＢＧ水平升高（ｔ＝ ２．７５，Ｐ＜ ０．０５）；两组空腹血清ＩＮＳ水平虽然无显著性差别（ｔ＝ ０．７７，Ｐ＞０．０５），但是经协方差分析纠正体质量因素后，实验组与对照组相比存在高胰岛素血症（Ｆ＝ ７．３３，Ｐ＜ ０．０５）；直线相关分析提示，实验组ＩＮＳ水平与ＢＷ 及ＳＢＰ呈高度正相关，对照组中ＩＮＳ水平亦与ＢＷ 呈高度正相关（ｒ＝ ０．７５６～０．９１５，Ｐ均＜ ０．０５，０．０１）。④结论 高糖摄入可显著升高正常ＳＤ大鼠的血压及ＦＢＧ，而胰岛素代谢紊乱可能在其中起重要作用。
Objective To observe the effect of high glucose on blood pressure, glucose and insulin metabolism in normal Sprague-Dawley rats. Methods Sixteen male Sprague Dawley rats were randomly divided into two groups. The experimental group was fed with 120g / L of sucrose for 42 days in the experimental group, and the control group was given normal drinking water. The body mass (BW) and systolic blood pressure SBP) and heart rate (HR). The blood samples were collected to measure the fasting blood glucose (FBG), serum insulin (INS) and so on. Results From the 8th day onwards, SBP and HR in the experimental group were higher than those in the control group, and continued until the end of the experiment (t = 2.18 ~ 5.60, P <0.05, 0.01) (T = 2.75, P <0.05). There was no significant difference in fasting serum INS levels between the two groups (t = 0.77, P> 0.05) Covariance analysis After correction of body mass factors, hyperinsulinemia was found in the experimental group as compared with the control group (F = 7.33, P <0.05). The linear correlation analysis indicated that the levels of INS in experimental group were significantly higher than those in BW and SBP There was a positive correlation between INS level and BW in the control group (r = 0.756-0.915, P <0.05, 0.01). ④ Conclusion High glucose intake can significantly increase blood pressure and FBG in normal SD rats, and insulin metabolism disorders may play an important role in them.