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[目的]对2005～2009年丰台区细菌性痢疾的病原菌型和最新的耐药性进行监测和分析,以更好的指导临床的诊断和用药。[方法]连续5年对临床诊断为细菌性痢疾的病人进行粪便培养,并对培养阳性的菌株进行分型鉴定,并对2009年获得的阳性菌株进行19种最新抗生素的药敏鉴定。[结果]从2005～2009年丰台区宋内和福氏菌株分布来看,优势菌型出现了明显变迁,宋内逐渐取代了福氏(χ2=45.58,P﹤0.01),而2009年的菌株耐药性鉴定结果显示多重耐药性严重,均在4重耐药以上,其中4重耐药和5重耐药的菌株占到94%。[结论]随着卫生条件的改善,引起细菌性痢疾的优势菌株也发生了变化,新菌株的药敏谱也发生了变化,医疗机构和疾病预防控制部门应根据这种变化,将医疗和预防措施进行适当的调整。
[Objective] To monitor and analyze the pathogenic bacteria and the latest drug resistance of bacillary dysentery in Fengtai District from 2005 to 2009 in order to better guide the clinical diagnosis and medication. [Method] The stool culture was carried out in patients with clinically diagnosed bacillary dysentery for 5 consecutive years, and the strains positive for culture were identified by typing. The sensitivity of 19 new antibiotics to the positive strains obtained in 2009 was identified. [Result] From 2005 to 2009, the distribution of dominant bacteria in Songneng and Forsythia strains in Fengtai District showed obvious changes. In Song Dynasty, they gradually replaced Freunds (χ2 = 45.58, P <0.01) Drug resistance identification results showed that the multi-drug resistance is serious, all above the 4-drug resistance, of which 4-drug resistance and 5-drug resistance strains accounted for 94%. [Conclusion] With the improvement of hygienic conditions, the dominant strains causing bacillary dysentery also changed, and the susceptibility spectrum of new strains also changed. Medical institutions and disease prevention and control departments should make medical and prevention based on this change Measures to make the appropriate adjustments.