热休克蛋白(heat shock protein,HSP)是生物界普遍存在的一种高度保守的蛋白质,对维持细胞生存和内环境的稳定起重要作用。在结核菌感染过程中机体或病原体的HSP被激活,影响巨噬细胞的自噬、凋亡和极化等作用。本文综述了结核菌感染中,能影响巨噬细胞功能的主要HSP的相关研究进展。 Heat shock protein (HSP) is a ubiquitously conserved protein in the organism that plays an important role in maintaining cell survival and the stability of the internal environment. In the course of Mycobacterium tuberculosis infection, the body or pathogen HSP is activated, which affects the autophagy, apoptosis and polarization of macrophages. This review summarizes the research progress of the major HSPs that can affect the function of macrophages during TB infection.