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目的 探讨肿节风注射液联合改良FOLFOX6化疗方案对晚期胃癌患者血清糖类抗原724(CA724)、糖类抗原199(CA199)、癌胚抗原(CEA)水平及生存质量的影响.方法 选取2016年11月—2018年11月42 例晚期胃癌患者,根据随机数表法分为对照组21 例,实验组21 例.对照组采用改良FOLFOX6化疗方案进行治疗,实验组在改良FOLFOX6化疗方案治疗的基础上予以肿节风注射液治疗,1 次/d.每一个治疗周期为14 d.两组患者均治疗两个周期.对比两组患者治疗后CA724、CA199、CEA血清学指标改善情况.观察并对比两组患者治疗前后卡氏评分变化情况.结果 对照组和实验组治疗后血清CA724、CA199、CEA水平同组比较均有显著降低,差异具有统计学意义(P＜0.05),且治疗后实验组血清CA724、CA199、CEA水平显著低于对照组,差异具有统计学意义(P＜0.05);对照组和实验组卡氏评分在治疗后均显著升高,且实验组卡氏评分升高更为显著.结论 肿节风注射液联合改良FOLFOX6化疗方案可显著降低晚期胃癌患者血清CA724、CA199、CEA水平,有助改善患者晚期临床症状,提高患者生存质量,具有一定的临床推广价值.“,”Objective To investigate the effects of Zhongjiefeng injection combined with modified FOLFOX6 chemotherapy on serum carbohydrate antigen 724 (CA724), carbohydrate antigen 199 (CA199) and carcinoembryonic antigen (CEA) levels and quality of life in patients with advanced gastric cancer. Methods 42 patients with advanced gastric cancer in the Fourth Affiliated Hospital of China Medical University from November 2016 to November 2018 were selected and divided into two groups, 21 patients in the control group and 21 patients in the experimental group according to the random number table method. The control group was treated with the modified FOLFOX6 chemotherapy, and the experimental group was treated with Zhongjiefeng injection on the basis of the modified FOLFOX6 chemotherapy, once a day. Each treatment cycle lasts 14 days. Patients in both groups were treated for two cycles. The improvement of serum indexes of CA724, CA199 and CEA was compared between the two groups after treatment. The change of Karnofsky score before and after treatment in the two groups was observed and compared. Results Serum CA724, CA199 and CEA levels of the control group and the experimental group were significantly decreased after treatment, with statistically significant differences (P＜0.05). Serum CA724, CA199 and CEA levels of the experimental group were significantly lower than those of the control group, with statistically significant differences (P＜0.05). The Karnofsky score of the two groups increased significantly after treatment, and the Karnofsky score of the experimental group increased more significantly. Conclusion The combination of Zhongjiefeng injection and the modified FOLFOX6 chemotherapy can significantly reduce the serum CA724, CA199 and CEA levels in patients with advanced gastric cancer, which can help improve the clinical symptoms and improve the quality of life of patients with advanced gastric cancer, and has certain clinical promotion value.