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胶质细胞源性神经营养因子(glial cell derived neurotrophic factor,GDNF)属转化生长因子β超家族成员,其成熟蛋白由134个氨基酸残基组成,而GDNF受体广泛分布于外周和中枢神经系统。GDNF不仅可以促进多巴胺能神经元、运动神经元的存活,对交感、副交感以及感觉神经元具有营养作用,还能够影响神经元的发育、分化并对非神经系统的发育也具有重要作用。近年来随着人们对疼痛认识的深入,疼痛的机制也不再限于神经元功能的改变,还受胶质细胞活化、多种营养因子、细胞因子及相应受体、离子通道等多方面因素的影响。为此,本文就近年来GDNF参与疼痛调节的相关研究进展做一简要综述。
Glial cell derived neurotrophic factor (GDNF) is a member of the transforming growth factor β superfamily. Its mature protein consists of 134 amino acid residues, while GDNF receptors are widely distributed in the peripheral and central nervous system. GDNF not only can promote the survival of dopaminergic neurons and motor neurons, but also can nourish the sympathetic, parasympathetic and sensory neurons. It can also affect the development and differentiation of neurons and play an important role in the development of non-nervous system. In recent years, with the deepening of people’s understanding of pain, the pain mechanism is no longer limited to changes in neuronal function, but also by the activation of glial cells, a variety of nutritional factors, cytokines and their receptors, ion channels and other factors influences. To this end, this article in recent years GDNF involved in the regulation of pain related research to make a brief review.