我们曾报导用光学活性试剂α-乙酰氧基-L-丙酰氯与外消旋2-丁醇反应,生成相应的一对非对映异构体酯,经气液分配色谱作定量测定,达到快速、微量分析其旋光异构体含量的目的。 为了进一步探讨这一方法对较高同系列醇类的适用性,我们选用外消旋2-辛醇作旋光异构体的定量分析。据Emanucl Gil-Ar等的报导,2-辛醇转变为相应的一对非对映异构体酯的反应时间即需数小时之久,且处理手续繁琐,难于应用于不对称合成中对 We have reported that the optically active reagent α-acetoxy-L-propionyl chloride is reacted with racemic 2-butanol to produce the corresponding pair of diastereomeric esters which are quantitatively determined by gas-liquid partition chromatography to Fast, trace analysis of its optical isomer content purposes. In order to further explore the applicability of this method to higher homologues of alcohols, we used racemic 2-octanol as a quantitative analysis of optical isomers. According to reports by Emanucl Gil-Ar et al., The reaction time of converting 2-octanol to the corresponding pair of diastereomeric esters takes several hours, and the handling procedures are cumbersome and difficult to apply in the asymmetric synthesis