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大脑皮层的兴奋性与抑制性平衡是维持正常脑功能的前提,而其失衡会诱发癫痫、帕金森、抑郁症等多种神经疾病,因此兴奋性与抑制性平衡的研究是脑科学领域的核心科学问题.反馈神经回路是脑皮层网络的典型连接模式,抑制性突触可塑性在兴奋性与抑制性平衡中扮演关键角色.本文首先构建具有抑制性突触可塑性的反馈神经回路模型;然后通过计算模拟研究揭示在抑制性突触可塑性的调控下反馈神经回路的兴奋性与抑制性可取得较高程度的动态平衡,并且二者的平衡对输入扰动具有较强的鲁棒性;其次给出了基于抑制性突触可塑性的反馈神经回路兴奋性与抑制性平衡机理的解释;最后发现反馈回路神经元数目有利于提高兴奋性与抑制性平衡的程度,这在一定程度上解释了为何神经元之间会存在较多的连接.本文的研究对于理解脑皮层的兴奋性与抑制性动态平衡机理具有重要的参考价值.
Excitability and inhibitory balance of the cerebral cortex is to maintain normal brain function, and its imbalance will induce epilepsy, Parkinson’s disease, depression and other neurological diseases, excitability and inhibitory balance of the brain is the core of the field of science Scientific issues: The feedback neural circuit is a typical connection mode of the cerebral cortex network, and inhibitory synaptic plasticity plays a key role in the excitability and inhibitory balance.This paper first builds a feedback neural circuit model with inhibitory synaptic plasticity, and then calculates Simulation studies revealed that the excitability and repression of feedback neural circuits under the control of inhibitory synaptic plasticity can achieve a higher degree of dynamic balance, and the balance between the two is robust to input disturbances. Secondly, Based on the inhibitory synaptic plasticity of the feedback neural circuit excitability and inhibition of the balance of the mechanism of interpretation; finally found that the number of feedback loop neurons is conducive to improving the degree of excitability and inhibitory balance, which to some extent explains why neurons There will be more connections between the study of this article to understand the excitability and inhibitory activity of the cortex Heng mechanism has important reference value.