论文部分内容阅读
Ca~(++)作为细胞内第二信使调节着许多组织细胞的生理功能,如肌肉收缩、神经冲动传导、细胞活性物质分泌等均有赖于 Ca~(++)的跨膜转运.Ca~(++)主要通过细胞膜钙通道(又称慢通道)进入细胞内发挥效应.钙通道阻滞剂(CCB)是通过阻断细胞钙通道,抑制 Ca~(++)内流达到调节细胞功能、治疗疾病的目的.自1967年 CCB 开始应用于临床以来,人们对其在高血压、冠心病、心律失常等治疗中的作用进行了大量研究,取得重大进展。近年来 CCB 作为平滑肌松弛剂也广泛应用于心血管系统以外的疾病,本文就 CCB 在呼吸系统疾病中的应
Ca ++ as intracellular second messenger regulates the physiological functions of many tissue cells such as muscle contraction, nerve impulse conduction and secretion of cellular active substances depend on the transmembrane transport of Ca ~ (++) (++) exerts its effect mainly through the cell membrane calcium channel (also known as slow channel) into the cell.Calcium channel blocker (CCB) is through the inhibition of cell calcium channel, inhibit Ca ~ (++) influx to regulate cell function , For the purpose of treating the disease.While the CCB started its clinical application in 1967, a great deal of research has been done on its role in the treatment of hypertension, coronary heart disease and arrhythmia, and great progress has been made. In recent years, CCB as a smooth muscle relaxant is also widely used in cardiovascular diseases other than the disease, this article on the CCB in respiratory diseases should