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１９８０年，Ｆｕｒｃｈｇｏｔ［１］首先发现乙酰胆碱（Ａｃｈ）的扩血管作用必须依赖内皮细胞释放的内皮源性舒张因子（ＥＤＲＦ）的介导。由于ＥＤＲＦ和一氧化氮（ＮＯ）药理特性极为相似，１９８７年，Ｉｇａｎｒｏ等［２］提出ＥＤＲＦ就是ＮＯ。之后不久，Ｐａｌｍ...
In 1980, Furchgot [1] first found that the vasodilatation of acetylcholine (Ach) must be mediated by the endothelium-derived endothelium-derived relaxing factor (EDRF). Since EDRF and nitric oxide (NO) pharmacological properties are very similar, in 1987, Iganro et al [2] proposed EDRF is NO. Shortly after, Palm ...