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目的通过对成都市新近艾滋病病毒(HIV)感染者耐药基因型的研究,了解本市HIV-1耐药毒株的传播水平。方法采用序贯抽样的方法,采集2013年4月-2013年8月16岁~25岁HIV感染者的血样57份,用In-house的方法扩增HIV-1 pol基因区1 160 bp片段,进行耐药基因型分析。结果在57份血样中获得47条有效分析序列,无样本出现耐药传播相关的突变位点。这些样本传播途径以性传播为主,其中同性恋占48.9%(23/47),异性传播占46.8%(22/47)。亚型分析表明,毒株以CRF07-BC为主(72.3%,34/47),其次为CRF01-AE(25.5%,12/47)。结论CRF01-AE和CRF07-BC是巴蜀地区最主要的HIV流行株。成都市HIV耐药株的传播处于低度水平,这也表明,目前成都市一线药物的治疗方案依然有效,不需要对个体患者在抗病毒治疗前进行耐药性检测。可在成都市继续开展HIV-1耐药警戒线调查。
Objective To understand the drug-resistant genotypes of HIV-infected persons in Chengdu and to know the level of transmission of HIV-1-resistant strains in this city. Methods A total of 57 blood samples were collected from HIV-infected individuals between 16 years old and 25 years old from April 2013 to August 2013 by sequential sampling method. The 1 160 bp fragment of HIV-1 pol gene was amplified by In-house method. Resistant genotypes were analyzed. Results In 47 blood samples, 47 validated sequences were obtained, and no mutation sites related to drug resistance were found in the samples. These samples were mainly transmitted sexually, with homosexuality accounting for 48.9% (23/47) and heterosexual transmission accounting for 46.8% (22/47). Subtype analysis showed that the strains were mainly CRF07-BC (72.3%, 34/47), followed by CRF01-AE (25.5%, 12/47). Conclusion CRF01-AE and CRF07-BC are the main HIV epidemic strains in BaShu area. Chengdu HIV-resistant strains of transmission at a low level, which also shows that the current treatment of first-line drugs in Chengdu is still valid, there is no need for individual patients before anti-viral treatment for drug resistance testing. In Chengdu, HIV-1 drug-resistant cordon can continue to be investigated.