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乙胺嘧啶乙胺嘧啶(Pyrimethamine,Daraprim),商品名“达拉匹林”:我国于1955年合成,并已大量生产。本品为白色无味无臭结晶粉末,微溶于醇,几不溶于水,熔点为238°-242℃。主要用于抗复发治疗和预防瘧疾,作用与氯脈相似,但毒性仅为氯胍的一半,服后皮肤不会染色。能抑制有性体在按蚊体内的发育,从而阻断瘧疾的传播。杀灭红血球内型的作用弱,奏效慢,因此不适用于现发病例的治疗。长期服用此药,可产生抗药性,尤其
Pyrimethamine (Daraprim), trade name “dalapirin”: China was synthesized in 1955 and has been mass-produced. This product is white odorless and odorless crystalline powder, slightly soluble in alcohol, some insoluble in water, the melting point of 238 ° -242 ℃. Mainly used for anti-relapse treatment and prevention of malaria, similar to the role of chlorine vein, but only half the toxicity of proguanil, after the skin will not be dyed. Can inhibit sexual development in an Anopheles, thus blocking the spread of malaria. Kill the role of endogenous red blood cells weak, slow, and therefore does not apply to the treatment of the current cases. Long-term use of this drug can produce drug resistance, especially