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很多基础和临床的科研单位目前在评价对体内肿瘤显象的标记抗体的应用问题,因为这些试剂提供一个非常灵敏和使诊断或治疗剂量的放射性核素能特异地送到全身的肿瘤部位的方法。为了了解多克隆和单克隆抗体在体内检测与肿瘤相关抗原(TAA)的能力,目前研究了许多不同抗体。已发现人绒毛膜促性腺激素((?)CG)的放射性碘标记的多克隆抗体特别适用在实验和临床上分泌这种糖蛋白的多种恶性肿瘤的检测。本研究目的之一是为了检测有高度特异性的小鼠单克隆抗体断片与hCG-β亚单位抗原起反应对体内肿瘤的检测是否有帮助。在本研究中所检测的单克隆抗体对hCG 具有很大的亲合力(接近10~(10)升/米),并对人体黄体激素(hLH)具有极低的交叉反应。它对人体促甲
Many basic and clinical research units are currently evaluating the use of labeled antibodies for in vivo tumor imaging since these reagents provide a very sensitive and specific method of delivering diagnostic or therapeutic doses of radionuclide to specific tumor sites throughout the body . In order to understand the ability of polyclonal and monoclonal antibodies to detect tumor-associated antigens (TAAs) in vivo, many different antibodies have been studied. Radioiodinated polyclonal antibodies to human chorionic gonadotropin (?) CG have been found to be particularly useful in the detection of a variety of malignancies that experimentally and clinically secrete this glycoprotein. One of the purposes of this study was to determine whether detecting a highly specific mouse monoclonal antibody fragment in response to the hCG-β subunit antigen would be useful in detecting in vivo tumors. The monoclonal antibodies tested in this study have a high affinity for hCG (approaching 10 to 10 liters per meter) and have very low cross-reactivity to human luteinizing hormone (hLH). It hurts the human body