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[目的]了解河南省细菌性痢疾发病规律,为制定防治措施提供依据。[方法]采用描述流行病学方法,对河南省2005～2009年细菌性痢疾发病资料、菌型检测、药敏试验和携带毒力基因情况进行分析。[结果]2005～2009年河南省细菌性痢疾发病率波动在16.15～31.51/10万之间,年均发病率23.43/10万。6～10月为发病高峰;各年龄组中5岁以下婴幼儿发病率最高,为110.85/10万,不同职业中农民发病最高,其次是散居儿童和学生。分离的流行菌株优势菌型是F2a、F4c和F1a,流行菌株对萘啶酸、四环素、利福平、氨苄西林和氯霉素高度耐药,对庆大霉素、环丙沙星、头孢噻肟、头孢噻吩耐药率逐年上升,耐7种以上抗生素的菌株达51.8%。有79.51%的菌株同时携带4种毒力基因。[结论]2005～2009年河南省菌痢发病率延续平稳下降趋势,流行菌株的菌型变化、耐药及多重耐药日益严重,毒力基因携带率高,给菌痢的防治工作带来了一定难度。
[Objective] To understand the pathogenesis of bacillary dysentery in Henan Province and provide basis for making prevention and cure measures. [Methods] The descriptive epidemiological method was used to analyze the incidence of bacterial dysentery, the detection of bacteria, the susceptibility testing and the virulence genes of bacterial dysentery from 2005 to 2009 in Henan Province. [Results] The incidence of bacterial dysentery in Henan Province fluctuated from 16.15 to 31.51 / 100 000 between 2005 and 2009, with an average annual incidence of 23.43 / 100 000. 6 to October peak incidence; the highest incidence of infants under 5 years of age in all age groups was 110.85 / 100 000, the highest incidence of peasants in different occupations, followed by scattered children and students. The predominant strains of the isolated strains were F2a, F4c and F1a. The strains were highly resistant to nalidixic acid, tetracycline, rifampicin, ampicillin and chloramphenicol. Gentamicin, ciprofloxacin, cefotaxime The rate of resistance to oxime and cefalotin increased year by year, reaching 51.8% of the strains resistant to more than seven antibiotics. 79.51% strains carried four virulence genes at the same time. [Conclusion] The incidence of dysentery in Henan Province continued to decline steadily from 2005 to 2009. The strains of the epidemic strains changed, the resistance and multi-drug resistance became more and more serious, the virulence gene carrying rate was high, which brought the control of bacillary dysentery A certain degree of difficulty.