肺癌是全球主要死因之一,长期吸烟导致了将近90%的肺癌。烟草会使肺细胞基因突变率大大提高,但肺癌细胞染色体存在大量基因多拷贝和重排,大量的噪音导致难以发现真正的致癌突变。随着测序技术迅猛发展,大规模基因组学研究极大地促进了我们对肺癌基因的了解。来自伦敦大学癌症研究中心和华盛顿大学医学院的查尔斯·斯旺顿(Charles Swanton)博士和拉马斯瓦米·戈尔迪(Ramaswamy Govindan)博士在《新英 Lung cancer is one of the leading causes of death in the world, with long-term smoking leading to nearly 90% of lung cancers. Tobacco will make the lung cell gene mutation rate greatly increased, but there are a large number of lung cancer cell chromosome duplication and rearrangement of genes, a large number of noises led to the discovery of true carcinogenic mutations. With the rapid development of sequencing technology, large-scale genomics research has greatly promoted our understanding of lung cancer genes. Dr. Charles Swanton and Dr. Ramaswamy Govindan, from the Cancer Research Center of University of London and the Washington University School of Medicine,