Objective This cross-sectional study aimed at investigating the intervention status and the influence of oncologists on oxaliplatin-induced hypersensitivity reactions (OIHR).Methods Snowball sampling was used to send questionnaires to oncologists in various provinces and cities in China, via the internet, to collect data on their socio-demographic characteristics, the occurrence of OIHR, and the current status of interventions. One-way ANOVA and T-test of geographic samples were used to explore the relationship between the incidence of OIHR and intervention measures. Results A total of 401 valid questionnaires were collected, most respondents were 30–40 years old, and most oncologists had 5 years of working experience. The proportions of glucocorticoid and H1 receptor antagonist use for OIHR prevention were 67.83％ and 38.65％, respectively. The proportion of oncologists with longer working years and higher professional titles who used glucocorticoids for OIHR prevention was higher, and the observed OIHR incidence was lower. Pretreatment with glucocorticoids may be an effective preventive measure and can reduce the incidence of the OXA allergic reactions (P < 0.05). Conclusion The risk awareness of junior oncologists to OIHR prevention should be strengthened, and clinical efficacy evaluation of glucocorticoids in OIHR prevention should be further promoted.