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Sutherland及其同事于1958年发现环腺苷一磷酸(cAMP),此后不久又发现了腺苷酸环化酶。激活腺苷酸环化酶或抑制cAMP磷酸二酯酶的制剂能增高细胞cAMP的水平。影响细胞辐射敏感性的制剂,已知有前列腺素E_1和Ro-20-1724[4-(3-丁氧基-4-甲氧苄基)-2-咪唑二酮],它们使细胞cAMP增高,其原因有二,一是刺激了腺苷酸环化酶,二是抑制了磷酸二酯酶。前列酶素E_1和Ro-20-1724于照射前加到CHO(中国田鼠卵巢)细胞中,增加了照射细胞的活存。
Sutherland and colleagues discovered cyclic adenosine monophosphate (cAMP) in 1958 and adenylate cyclase was discovered shortly thereafter. Formulations that activate adenylyl cyclase or inhibit cAMP phosphodiesterase can increase cellular cAMP levels. Preparations that affect the radiosensitivity of cells are known as prostaglandins E_1 and Ro-20-1724 [4-(3-butoxy-4-methoxybenzyl)-2-imidazoliedione], which increase cellular cAMP levels. There are two reasons for this. One is to stimulate adenylyl cyclase and the other is to inhibit phosphodiesterase. Prostaglandins E_1 and Ro-20-1724 were added to CHO (Chinese mouse ovary) cells prior to irradiation, increasing the viability of irradiated cells.