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本文报告48例白癜风组织形态学的研究,证明了进行性白癜风的斑片与正常色素的邻接处存在着单一核细胞的聚积。作者将患者分活跃、静止、改善和带状疱疹样4期。活跃20例;静止10例;改善12例;带状疱疹样6例。活检选择临床上无炎症及浸润的皮损,在边缘处钻孔取7毫米直径的组织,对分为两块,均包含有白癜风及正常皮肤部分,一块做Dopa染色,另一块做HE染色,每个蜡块做成5微米厚度的连续切片。又作特殊染色以显示基底膜及肥大细胞。每病例观察切片约60～90张(包括特殊染色)。结果各期有单一核细胞聚积的发生率是:活跃期检查20例有17例;静止期10例有6例;改善期12例有6例;带状疱疹样期6例有6例。
This paper reports on the histomorphological study of vitiligo in 48 cases, which proves that there is accumulation of mononuclear cells adjacent to the normal pigment in patches of progressive vitiligo. The author classified the patient as active, restless, ameliorative, and herpes zoster-like 4. Active in 20 cases; rest in 10 cases; improvement in 12 cases; herpes zoster-like in 6 cases. The biopsy selected clinically no inflammation and infiltrative lesions, and drilled 7 mm diameter tissue at the edges. The pair was divided into two pieces, each containing vitiligo and normal skin. One piece was stained with Dopa and the other piece was stained with HE. Each wax block was made into 5 micron thick slices. Special staining was performed to show the basement membrane and mast cells. About 60 to 90 slices (including special staining) were observed in each case. Results The incidence of mononuclear cell accumulation in each period was as follows: 17 cases in 20 cases in active stage, 6 cases in 10 cases in rest period, 6 cases in 12 cases in improvement period, and 6 cases in 6 cases in herpes zoster.